Pixeloo shares the technique on bringing Jessica Rabbit out of the animated world vis this 10 breakdown of the first hour of Untooning Jessica Rabbit.
For some reference, here’s Pixeloo’s Jessica Rabbit (along with source image):

I can’t say Angelina Jolie makes the best real-world comparison (she’s just far too otherworldly looking to me), but there you have it.
In your face, Donnie